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For her entire adult life, Oprah Winfrey has struggled with her weight. She never thought in her lifetime, medicines would provide hope, health, and healing for people like her. But as her conversations with Dr. Ania Jastreboff from the Yale School of Medicine reveal, we’ve learned that having obesity is not a choice. It’s not a question of willpower. Obesity is a disease. It’s a question of biology, created by our bodies'' need to survive and the environment we created and now live in. And it’s treatable. The new medications can lower our body fat set point (our brain’s ''Enough Point''), so that we lose weight without battling biology with willpower. Dr. Jastreboff describes strategies to optimise health and manage side effects all with the reassuring perspective of decades of experience treating patients with obesity and leading studies with these medications. Many of her patients say